Bioprinting of three-dimensional scaffold based on alginate-gelatin as soft and hard tissue regeneration

• DOI: 10.1016/j.jmrt.2021.08.069
• Publication Date: 2021-08-24T16:23:10Z
• Authors: Pedram Iranmanesh; Mohammad Gowdini; Abbasali Khademi; Mohammad Dehghani; Mehran Latifi; Naif Alsaadi; Mehran Hemati; Ramin Mohammadi; Saeed Saber-Saman...; Davood Toghraie; Afrasyab Khan
• Keywords: Gelatin; 3D bioprinting

Three dimensional bioprinter technologies created an availability to use alive cells and molecules replace or repair a damaged part of the body. In this paper, novel alginate-gelatin hydrogel using BioFab X4 with bioink cured UV was produced. The designed architecture fabricated cubic shape then coated various content naproxen drug estimate its release biological response. scaffolds were investigated for mechanical properties (porosity tensile strength) features (biodegradation pH changes). bioprinted samples analyzed Scanning Electron Microscope (SEM) X-Ray Diffraction (XRD) techniques. obtained outcome indicated that has especial response compares pure specimen. specimen strength increase from 64 kPa 79 as eliminate surface scaffold. morphological structural coats show addition may adhesion polymers chemical bonds encounter higher toughness via coats. printed 78 belong sample 4% 6% coating. concentration shows coat non-coat does not create acidic environment after soaking specific time in SBF physiological saline. However, degradation rate increases 0.18 0.27 PBS. results demonstrated ink is fully compatible