Decellularized and biological scaffolds in dental and craniofacial tissue engineering: a comprehensive overview

• DOI: 10.1016/j.jmrt.2021.08.083
• Publication Date: 2021-08-30T15:40:13Z
• Authors: Mohsen Yazdanian; Arian Hesam Arefi; Mostafa Alam; Kamyar Abbasi; Hamid Tebyaniyan; Elahe Tahmasebi; Reza Ranjbar; Alexander Seifalian; Mahdi Rahbar
• Keywords: Decellularization; Regenerative Medicine; Hard tissue

Dental problems including cavities, periodontitis, apical and pulpitis are among the most cost-consuming burden for both patients health care system all over world. The pathological consequences of these complications importantly lead to tooth loss causing functional psychological conflictions patients. traditional treatment includes removing impaired or its restoration using hard restorative materials that supposed mimic tissue enamel dentine whereas cannot simulate chemical, biological, physical characteristics a natural tooth. Therefore, different daily-progressing methods engineering (TE) being propounded as new promising approaches managing dentistry conflicts. TE is now considered almost practical, reproducible, clinically safe therapy regenerating oral dental tissues either whole organ various anatomical parts. necessarily constitutes three angles stem cell (SC), scaffold, essential growth factors (GFs). Generally, scaffolds can be made decellularized (usually containing extra-cellular matrix (ECM) target organs tissues) biologic (containing polymer). current study aims review studies conducted in recent decade on biological their potential applications modern regenerative dentistry.