Osteogenic differentiation of bone marrow stromal stem cells on a novel β titanium alloy-based micro-nano composite

• DOI: 10.1016/j.jmrt.2023.04.188
• Publication Date: 2023-04-25T18:11:11Z
• Authors: Wenyue Yang; Xiao Liu; Yingjing Fang; Shokouh Attarilar; Chenyuan Zhu; Liqiang Wang; Qing Luo; Yuanfei Fu
• Keywords: RUNX2; Titanium alloy

The incorporation of nanoparticles into metallic biomaterials has been recognized as a significant approach to improve their bioactivity for biomedical applications. In this study, friction stir processing (FSP) was employed incorporate TiO2 bioactive reinforcement the β titanium alloy Ti–35Nb–2Ta–3Zr (TNTZ) matrix construct an integrated micro-nano composite layer. effect different contents on osteogenic capacity rat bone marrow stromal stem cells (BMSCs) studied. TiO2/TNTZ layer exhibited refined grain structure with mean size approximately 10 μm and characteristic surface morphology pronounced peaks valleys enhanced RSkw RKur values. Moreover, significantly promoted adhesion, proliferation, spreading BMSCs, upregulated expression genes related osteogenesis (ALP Runx2) up nearly 1.5 times, ALP OCN (P < 0.05). novel FSPed possesses excellent characteristics favorable biological activities, manifesting vast potential upcoming clinical