The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas

• DOI: 10.1016/j.jneuroim.2013.04.009
• Publication Date: 2013-05-09T16:32:06Z
• Authors: Marco Locatelli; Stefano Ferrero; Filippo Martinell...; Leonardo Boiocchi; Mario Zavanone; Sergio Maria Gaini; Lorenzo Bello; Sonia Valentino; Elisa Barbati; Manuela Nebuloni; Alberto Mantovani; Cecilia Garlanda
• Keywords: PTX3

Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation. In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy.