Role of prolactin in B cell regulation in multiple sclerosis
Adult
Male
B-Lymphocytes
Multiple Sclerosis
Middle Aged
Prolactin
03 medical and health sciences
Multiple Sclerosis, Relapsing-Remitting
0302 clinical medicine
Humans
Female
Biomarkers
DOI:
10.1016/j.jneuroim.2014.02.007
Publication Date:
2014-02-24T16:32:34Z
AUTHORS (3)
ABSTRACT
The role of prolactin in MS pathogenesis was investigated. Prolactin levels were higher in MS subjects both during remission and exacerbation compared to control subjects. Prolactin increased JAK2 expression and Stat phosphorylation on B cells, up-regulated anti-MOG antibody secreting cell numbers, BAFF levels, and Bcl-2expression, and down-regulated expression of Trp63. Prolactin levels correlated positively with anti-MOG secreting cell numbers, and negatively with induced apoptotic B cells. Additionally, prolactin decreased B cell receptor-mediated activation threshold, and induced CD40 expression in B cells. These findings suggest that prolactin promotes B cell autoreactivity in MS through different mechanisms.
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