Brain stem encephalitis is a rare complication of COVID-19

• DOI: 10.1016/j.jneuroim.2022.578007
• Publication Date: 2022-11-28T00:33:10Z
• Authors: Marc C. Shamier; Yvette S. Crijnen; Susanne Bogers; Jeroen W. IJpelaar; Juna M. de Vries; Mathieu van der Jagt; Jochem K.H. Spoor; Jan H. von der Th...; Marco W.J. Schreurs; Corine H. Geurtsv...; Maarten J. Titulaer
• Keywords: Etiology; Viral encephalitis; 2019-20 coronavirus outbreak

Here, we describe the clinical phenotype of SARS-CoV-2-related CNS disease and evaluate SARS-CoV-2 antibody index as a tool to differentiate between direct (viral) indirect etiology. Out >4000 hospitalized patients with COVID-19, included 13 neurological symptoms suspicion neuroinflammation. On grounds, eight were classified having possible/probable relationship COVID-19. A clinically distinctive brainstem cerebellar was seen in 6/8 patients. As found positive 3/5 patients, indicating specific intrathecal IgG production, link is likely.