Brain stem encephalitis is a rare complication of COVID-19
03 medical and health sciences
0302 clinical medicine
SARS-CoV-2
Short Communication
Immunoglobulin G
Humans
COVID-19
Encephalitis
Antibodies, Viral
Brain Stem
3. Good health
DOI:
10.1016/j.jneuroim.2022.578007
Publication Date:
2022-11-28T00:33:10Z
AUTHORS (11)
ABSTRACT
Here, we describe the clinical phenotype of SARS-CoV-2-related CNS disease and evaluate the SARS-CoV-2 antibody index as a tool to differentiate between a direct (viral) and indirect etiology. Out of >4000 hospitalized patients with COVID-19, we included 13 patients with neurological symptoms with suspicion of neuroinflammation. On clinical grounds, eight were classified as having a possible/probable relationship between neurological symptoms and COVID-19. A clinically distinctive phenotype of brainstem and cerebellar symptoms was seen in 6/8 patients. As we found a positive SARS-CoV-2 antibody index in 3/5 patients, indicating specific intrathecal SARS-CoV-2 IgG production, a direct link with SARS-CoV-2 is likely.
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