Sugar-sweetened beverages exacerbate high-fat diet-induced inflammatory bowel disease by altering the gut microbiome

• DOI: 10.1016/j.jnutbio.2022.109254
• Publication Date: 2022-12-24T00:58:44Z
• Authors: Woo-Jeong Shon; Min Ho Jung; Younghoon Kim; Gyeong Hoon Kang; Eun Young Choi; Dong-Mi Shin
• Keywords: Pathogenesis; Dietary Sucrose

High-fat diets (HFDs) and frequent consumption of sugar-sweetened beverages (SSBs) are potential contributors to increasing inflammatory bowel disease (IBD) incidences. While HFDs have been implicated in mild intestinal inflammation, the role sucrose SSBs remains unclear. Therefore, we studied IBD pathogenesis a mouse model humans. C57BL6/J mice were given ad libitum access solution or plain water for 10 weeks, with without an HFD. Interestingly, alone did not induce gut inflammation mice; however, when combined HFD, it dramatically increased score, submucosal edema, CD45+ cell infiltration. 16S ribosomal RNA gene-sequencing revealed that HFD co-consumption significantly relative abundance IBD-related pathogenic bacteria compared consumption. sequencing flow cytometry showed promoted pro-inflammatory cytokine chemokine synthesis, dendritic-cell expansion, IFN-γ+TNF-α+CD4+ CD8+ T-cell activation. Fecal microbiota transplantation from HFD- water-fed into gut-sterilized susceptibility dextran sulfate sodium-induced colitis recipient mice. Consistent herewith, high animal fat-rich markedly systemic inflammation-associated marker expression In conclusion, exacerbate HFD-induced by triggering shift microbiome pathobiome. Our findings provide new insights development strategies aimed at preventing IBD.