Comparison of the dietary omega-3 fatty acids impact on murine psoriasis-like skin inflammation and associated lipid dysfunction

• DOI: 10.1016/j.jnutbio.2023.109348
• Publication Date: 2023-04-11T06:24:56Z
• Authors: Alexander V. Sorokin; Hildur Arnardottir; Maryia Svirydava; Qimin Ng; Yvonne Baumer; Alexander Berg; Carla J. Pantoja; Elizabeth M. Florida; Heather L. Teague; Zhi-Hong Yang; Pradeep K. Dagur; Tiffany M. Powell...; Zu-Xi Yu; Martin P. Playford; Alan T. Remaley; Nehal N. Mehta
• Keywords: Inflammation; Mice; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Fatty Acids; Animals; Psoriasis; 3. Good health; Diet

Persistent skin inflammation and impaired resolution are the main contributors to psoriasis associated cardiometabolic complications. Omega-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA), docosahexaenoic (DHA), known exert beneficial effects on inflammatory response lipid function. However, a specific role of omega-3 PUFAs in accompanied pathologies still matter debate. Here, we carried out direct comparison between EPA DHA 12 weeks diet intervention treatment psoriasis-like K14-Rac1V12 mouse model. By utilizing sensitive techniques, targeted EPA- DHA-derived specialized pro-resolving mediators identified tightly connected signaling pathways by RNA sequencing. Treatment with experimental diets significantly decreased circulating pro-inflammatory cytokines bioactive mediators, altered macrophage phenotypes genes oxidation. The superficial these changes was related included increased levels resolvin D5, protectin DX maresin 2 skin. treated mice had less pronounced but demonstrated accumulation prostaglandin E2 thromboxane B2. These results indicate that modulating may have clinical significance might be considered over this disease.