Signal intensity and volume of carotid intraplaque hemorrhage on magnetic resonance imaging and the risk of ipsilateral cerebrovascular events: The Plaque At RISK (PARISK) study

• DOI: 10.1016/j.jocmr.2024.101049
• Publication Date: 2024-06-13T19:35:30Z
• Authors: Kelly P.H. Nies; Mueez Aizaz; Dianne H.K. van D...; Timothy C.D. Goring; Tobien A.H.C.M.L....; Narender P. van O...; Alida A. Postma; Daniel Bos; Jeroen Hendrikse; Paul Nederkoorn; Rob van der Geest; Robert J. van Oos...; Werner H. Mess; M. Eline Kooi
• Keywords: Angiology

The Plaque at RISK (PARISK) study demonstrated that patients with a carotid plaque intraplaque hemorrhage (IPH) have an increased risk of recurrent ipsilateral ischemic cerebrovascular events. It was previously reported symptomatic plaques IPH showed higher signal intensity ratios (SIR) and larger volumes than asymptomatic plaques. We explored whether SIR volume are associated future events beyond the presence IPH. TIA stroke mild-to-moderate stenosis IPH-positive (n=89) from PARISK were included. clinical endpoint new event during 5 years follow-up, while imaging-based brain infarct on MRI after 2 (n=69). Trained observers delineated IPH, hyperintense region compared to surrounding muscle tissue hyper T1-weighted MR images. maximal in divided by mean adjacent tissue. associations between or investigated using Cox-proportional hazard models logistic regression, respectively. During 5.1 (interquartile range (IQR): 3.1-5.6) 21 identified. Twelve infarcts identified 2-year neuro MRI. There no association for (HR: 0.89 [95% CI: 0.67-1.10] HR: 0.91 [0.69-1.19] per 100 µl increase, respectively) nor (OR: 1.04 [0.75-1.45] OR: 1.21 [0.87-1.68] respectively). not Therefore, quantitative assessment does seem provide additional value assessment. Trial registration registered ClinicalTrials.gov ID NCT01208025 September 2010 (https://clinicaltrials.gov/study/NCT01208025).