Nomogram prediction model called “ADPLCP” for predicting linezolid-associated thrombocytopenia in elderly individuals

• DOI: 10.1016/j.jointm.2022.12.003
• Publication Date: 2023-03-04T05:37:31Z
• Authors: Yanxin Liu; Jiang Wang; Tingting Liu; Kun Xiao; Peng Yan; Xiangqun Fang; Lixin Xie
• Keywords: Nomogram; Linezolid

Linezolid-associated thrombocytopenia (LAT) leads to drug withdrawal associated with a poor prognosis. Some risk factors for LAT have been identified; however, the sample size of previous studies was small, data from elderly individuals are limited, and simple score scale not established predict at an early stage, making it difficult identify intervene in stage.In this single-center retrospective case-control study, we enrolled patients treated linezolid intensive care unit January 2015 December 2020. All patients, including demographic information laboratory findings baseline, were collected. We analyzed incidence nomogram prediction model population.A total 428 enrolled, 35.5% (152/428). Age ≥80 years old (OR=1.980; 95% CI: 1.179-3.325; P=0.010), duration ≥ 10 days (OR=1.100; 1.050-1.152; P <0.0001), platelet count baseline (100-149×109/L vs. ≥200×109/L, OR=8.205, 4.419-15.232, <0.0001; 150-199 ×109/L OR=3.067, 1.676-5.612, <0.001), leukocyte ≥16×109/L (OR=2.580; 1.523-4.373; creatinine clearance <50 mL/min (OR=2.323; 1.388-3.890; P=0.001), protein <60 g/L (OR=1.741; 1.039-2.919; P=0.035) LAT. The called "ADPLCP" (age, duration, platelet, leukocyte, clearance, protein) based on logistic regression. area under curve (AUC) ADPLCP 0.802 (95% 0.748-0.856; 78.9% sensitivity 69.2% specificity (cut-off 108). Risk stratification performed "ADPLCP." Total points <100 defined as low risk, possibility <32.0%. 100-150 medium 32.0-67.5%. A point >150 high probability >67.5%.We created occurrence individuals. is feasible helpful determination guide or intervention.