Hyaluronidase Increases the Duration of Mepivacaine in Inferior Alveolar Nerve Blocks

• DOI: 10.1016/j.joms.2007.06.628
• Publication Date: 2008-01-16T17:14:41Z
• Authors: Anna Carolina Rat...; Mayara Aguilar Di...; Flávio Eduardo Gu...; Maria Prazeres Ba...; Rodney Garcia Rocha; Maria Aparecida B...
• Keywords: Adult; Male; Time Factors; Adolescent; Epinephrine; Anesthesia, Dental; Dental Pulp Test; Mandibular Nerve; Gingiva; Hyaluronoglucosaminidase; Drug Synergism; Nerve Block; 03 medical and health sciences; 0302 clinical medicine; Mepivacaine; Humans; Female; Molar, Third; Anesthetics, Local; Epidemiologic Methods; Dental Pulp; Adjuvants, Anesthesia

To evaluate the duration of the effect of mepivacaine when hyaluronidase is injected immediately prior to the end of pulpal anesthesia.Forty bilateral, symmetrical third molar surgeries were performed in 20 healthy patients. Inferior alveolar nerve block was induced using 2.8 mL 2% mepivacaine with epinephrine. Hyaluronidase (75 turbidity-reducing units) or a placebo was injected 40 minutes after the beginning of pulpar anesthesia (randomized and double-blind trial). The duration of effect in the pulpal and gingival tissues was evaluated by response to painful electrical stimuli applied to the adjacent premolar, and by mechanical stimuli (pin prick) to the vestibular gingiva, respectively.In both tissues, the duration of anesthetic effect with hyaluronidase was longer (P < .01) than with the placebo.Hyaluronidase increases the duration of mepivacaine in inferior alveolar nerve blocks.