The potential of herbal drugs to treat heart failure: The roles of Sirt1/AMPK

• DOI: 10.1016/j.jpha.2023.09.001
• Publication Date: 2023-09-27T15:51:10Z
• Authors: Tao Zhang; Lei Xu; Xiaowei Guo; Honglin Tao; Yue Liu; Xianfeng Liu; Yi Zhang; Xianli Meng
• Keywords: AMP-Activated Protein Kinase; Adenosine monophosphate

Heart failure (HF) is a highly morbid syndrome that seriously affects the physical and mental health of patients generates an enormous socio-economic burden. In addition to cardiac myocyte oxidative stress apoptosis, which are considered mechanisms for development HF, alterations in energy metabolism pathological autophagy also contribute abnormalities ultimately HF. Silent information regulator 1 (Sirt1) adenosine monophosphate-activated protein kinase (AMPK) nicotinamide adenine dinucleotide (NAD