Cervicovaginal microbiome in patients with recurrent pregnancy loss

• DOI: 10.1016/j.jri.2023.103944
• Publication Date: 2023-04-07T15:01:22Z
• Authors: Ryosuke Mori; Takashi Hayakawa; Masaaki Hirayama; Fumiko Ozawa; Hiroyuki Yoshihara; Shinobu Goto; Tamao Kitaori; Yasuhiko Ozaki; Mayumi Sugiura-Og...
• Keywords: Ureaplasma

There have been few studies concerning an association between unexplained recurrent pregnancy loss (RPL) and the microbiome. A recent study including 67 patients demonstrated that increase in Ureaplasma species endometrium raised risk of miscarriage with euploid karyotype. While endometrial sampling is invasive, cervicovaginal not. We compared vaginal cervical microbiomes a 16 S ribosomal RNA sequence 88 RPL 17 healthy women no history miscarriage. prospectively assessed factors for maternal colonization at subsequent without aneuploid karyotype patients. Cervicovaginal bacteria were dominated by Lactobacillus iners, Gardnerella vaginalis, Atopobium vaginae Bifidobacterium breve Japanese population. The proportions Delftia unknown cervix significantly higher than controls. Streptococcus, Microbacterium, Delftia, Anaerobacillus Chloroplast chorioamnionitis to abundance Cutibacterium was who had subsequently miscarried those gave birth. rate both (66.7%, 2/3) greater lacked these (9.2%, 6/65, adjusted odds ratio 16.90, 95% confidence interval 1.27-225.47, p = 0.032). presence certain could be predictor microbiome might useful investigating possible cause RPL.