Design, synthesis and docking studies of new hydrazinyl-thiazole derivatives as anticancer and antimicrobial agents

• DOI: 10.1016/j.jscs.2022.101488
• Publication Date: 2022-05-20T06:31:41Z
• Authors: Abeer M. El-Naggar; Alaa Zidan; Eslam B. Elkaeed; Mohammed S. Taghour; Waleed A. Badawi
• Keywords: Thiazole; IC50; MTT assay; Docking (animal)

Increase in the number of infections caused by pathogenic microbes cancer patients has prompted searcher to invest development agents having dual anticancer and antimicrobial properties. The present study is concerned with synthesis screening for activity a series 5-hydrazinyl-2-(2-(1-(thien-2-yl)ethylidene)hydrazinyl)thiazole derivatives. structure elucidation synthesized hydrazinyl thiazole derivatives was illustrated spectroscopic elemental analysis. All newly compounds 5a-p were evaluated in-vitro cytotoxic against breast carcinoma (MCF-7 cell line), hepatocellular (HePG-2) colorectal (HCT-116) lines using MTT assay method. Compounds 5 g, 5h showed broad spectrum three IC50 ranged from 3.81 11.34 µM compared reference drug Roscovitine (IC50 = 9.32 13.82 µM), while l m found be more selective HePG-2 HCT-116 line 9.29 8.93 respectively) compound 5j MCF-7 6.73 10.87 respectively). inhibitory most promising tested EGFR ARO enzymes further apoptosis Annexin V/PI staining. results enzyme-based tests revealed that effect on 82.8 98.6 nM respectively drugs Erlotinib Letrozole 62.4 79 Furthermore, majority exhibited significant used species. 4b, 5h, exerted good antibacterial antifungal all microbes. Therefore, it concluded h, proved possess agent may serves as useful lead search modification or derivatization give potent agents.