N-Arylpyrazole based Scaffolds: Synthesis and biological applications

• DOI: 10.1016/j.jscs.2024.101861
• Publication Date: 2024-04-24T16:39:55Z
• Authors: Sumayya Akram; Tooba Jabeen; Sana Aslam; Amnah Yusaf; Matloob Ahmad; Muhammad Shahid N...; Sami A. Al-Hussain; Magdi E.A. Zaki
• Keywords: Synthesis; Chemistry; N-arylation; Biological activity; Pyrazoles; QD1-999; 01 natural sciences; Metal-catalyzed cross coupling reaction; 0104 chemical sciences

N-Arylpyrazoles are important building blocks in many biologically active compounds, natural products, pharmaceuticals, and industries. It is an important moiety of various drugs and exhibits extensive biological activities viz., antibiotic, anticancer, antifungal, anti-inflammatory, anti-coagulant, analgesic, antipyretic, anti-depressant, insecticidal, and hyperglycemic activities. Various protocols have been designed for the synthesis of N-arylpyrazoles facilitated by a wide variety of metal-based catalysts at high or room temperature, metal free reactions, various named reactions, multicomponent reactions, and those occurring under different electromagnetic radiations. Various ligands are found to promote Cu-catalyzed N-arylation of pyrazole under mild conditions in short time. This review describes the synthesis and biological applications of N-arylpyrazole derivatives reported during 2019–2023.