Contribution of momilactones A and B to diabetes inhibitory potential of rice bran: Evidence from in vitro assays

• DOI: 10.1016/j.jsps.2019.03.006
• Publication Date: 2019-03-15T08:02:35Z
• Authors: Nguyen Van Quan; Tran Dang Xuan; Hoang-Dung Tran; Ateeque Ahmad; Tran Dang Khanh; Tran Dang Dat
• Keywords: Alpha-glucosidase

This study was the first to detect presence of two compounds momilactone A (MA) and B (MB) in rice bran using liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS). By vitro assays, both MA MB exhibited potent inhibitory activities on pancreatic α-amylase α-glucosidase which were significantly higher than γ-oryzanol, a well-known diabetes inhibitor. Remarkably, indicated an effective inhibition trypsin with IC