A detailed biochemical characterization, toxicological assessment and molecular docking studies of Launaea fragilis: An important medicinal xero-halophyte

• DOI: 10.1016/j.jsps.2023.04.028
• Publication Date: 2023-05-06T01:45:00Z
• Authors: Duraiz Ahmed Khan; Afia Shahid; Asmaa E. Sherif; Hanan Y. Aati; Muhammad Abdullah; Khalid Mehmood; Musaddique Hussain; Abdul Basit; Bilal Ahmad Ghalloo; Kashif ur Rehman ...
• Keywords: Docking (animal)

Launaea fragilis (Asso) Pau (Family: Asteraceae) is a wild medicinal plant that has been used in the folklore as potential treatment for numerous ailments such skin diseases, diarrhea, infected wounds, inflammation, child fever and hepatic pain. This study explored chemical constitution, in-vivo toxicity, antimicrobial, antioxidant, enzyme inhibition of ethanolic extract L. (EELF). Additionally, in-silico docking studies predominant compounds were performed against in-vitro tested enzymes. Similarly, ADMET properties to determine their pharmacokinetics, physicochemical properties, toxicity profiles. The EELF was found rich TFC (73.45 ± 0.25 mg QE/g) TPC (109.02 0.23 GAE/g). GC-MS profiling indicated presence total 47 mainly fatty acids essential oil. showed no or growth retardation chicks up 300 mg/kg with effect on biochemistry hematology chicks. gave promising antioxidant activity through CUPRAC method an IC50 value 13.14 0.18 µg/ml. highest tyrosinase followed by acetylcholinesterase α-Glucosidase detected. antimicrobial revealed good antibacterial antiviral activity. A score observed silico computational compounds. findings biocompatible, potent therapeutic alternative suggest isolation further vivo pharmacological studies.