Trousseau Syndrome Related Cerebral Infarction: Clinical Manifestations, Laboratory Findings and Radiological Features

• DOI: 10.1016/j.jstrokecerebrovasdis.2020.104891
• Publication Date: 2020-06-30T10:30:36Z
• Authors: Lei Bao; Shenyang Zhang; Xiangyao Gong; Guiyun Cui
• Keywords: Aged, 80 and over; Male; Thrombosis; Cerebral Infarction; Syndrome; Adenocarcinoma; Middle Aged; Prognosis; Up-Regulation; 3. Good health; Fibrin Fibrinogen Degradation Products; 03 medical and health sciences; Diffusion Magnetic Resonance Imaging; 0302 clinical medicine; Antigens, Neoplasm; Predictive Value of Tests; Risk Factors; Humans; Female; Biomarkers; Aged; Retrospective Studies

We summarized the clinical manifestations, laboratory data, and brain MRI of patients with Trousseau syndrome related cerebral infarction and compared them to patients with other types of cerebral infarction. Through our present research, we hope to aid the neurologists in recognizing and diagnosing this syndrome.A total of 31 patients at our institution were identified with cerebral infarction resulting from Trousseau syndrome. We have also selected the 180 patients who have suffered from cerebral infarction as control groups and these patients were distributed to large-artery atherosclerosis group; cardio-embolism group; small-artery occlusion group, according to Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. The clinical data and neuroimage of these patients were collected.All our 31 cancer patients were confirmed by pathological biopsy to be adenocarcinomas and the most common cancers are gastric and lung cancers. Patients with Trousseau syndrome exhibited high serum carbohydrate antigen CEA, CA 125 and CA 199 levels. Compared to patients with other types of cerebral infarction, patients with Trousseau syndrome had an increased severity and worse prognosis. Besides, patients had the highest mean level of plasma D-dimer. We also found multiple lesions in multiple vascular territories was the most frequent type of DWI patterns in patients of Trousseau syndrome.Trousseau syndrome can progress rapidly and become life-threatening. For patients who developed unexplained cerebral infarction involving multiple arterial territories, with elevated plasma D-dimer and cancer antigens, Trousseau syndrome should always be considered.