The impact of cumulative exposure to diverse lipid profiles on carotid intima-media thickness among an asymptomatic population

• DOI: 10.1016/j.jstrokecerebrovasdis.2023.107443
• Publication Date: 2023-10-28T21:46:31Z
• Authors: Yu Wang; Guanyi Zhang; Jianwei Wu; Anxin Wang; Xiaoli Zhang; Jia Zhang; Shouling Wu; Xingquan Zhao; Qian Zhang
• Keywords: Intima-media thickness

Background and AimsWe aimed to investigate the relationship between cumulative exposure different lipid parameters carotid intima-media thickness(CIMT), which is considered a marker for early stage of atherosclerosis. This due shift in research focus from assessing individual lipoproteins considering their exposure.Methods ResultsThe study included 2,348 participants who had measured biennially since 2006.To calculate burden, weighted sum difference value cutoff each parameter, including total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDLC), high-density (HDLC), non-HDLC, was added. Carotid ultrasound used detect CIMT. The association burden CIMT evaluated using linear logistic analyses. TC LDLC were significantly associated with thickening (p<0.05). A 2.65-fold, 1.67-fold increased risk abnormal documented highest quartile these two burdens. Notably, dose-dependent observed overall population when taking non-HDLC as continuous variable (fully-adjusted β coefficient=0.0013, 95%CI 0.0004-0.0022).ConclusionsOut five parameters, showed independent associations it crucial attain optimal levels prevention treatment subclinical