Incidence and Outcome of Atypical Manifestations of Chronic Graft-versus-Host Disease: Results From a Retrospective Single-Center Analysis

• DOI: 10.1016/j.jtct.2023.09.016
• Publication Date: 2023-09-28T21:43:58Z
• Authors: Jana Doering; Markus Perl; Daniela Weber; Bernhard Banas; Christian Schulz; Okka W. Hamer; Klemens Angstwurm; Ernst Holler; Wolfgang Herr; Matthias Edinger; Daniel Wolff; Matthias A. Fante
• Keywords: Single Center; Serositis

Chronic graft-versus-host disease (cGVHD) is the leading cause of late nonrelapse mortality (NRM) after allogeneic hematopoietic stem cell transplantation (alloHSCT) and defined by 8 diagnostic target organs. Recently, provisional criteria for atypical manifestations cGVHD that include in nonclassic organs as well National Institutes Health (NIH)-defined organs, were proposed a NIH task force. Little known about incidence, risk factors, impact on survival cGVHD, however. The aim present study was to analyze these parameters sequential patient population. We retrospectively screened 623 patients who underwent alloHSCT at University Medical Center Regensburg between January 2008 December 2020 manifestations, applying taskforce criteria. A total 102 (16.4%) met criteria, representing 25% all cases, 14 (2.2%) had only cGVHD. most frequent immune-mediated cytopenias (24.5%), renal (13.7%) (poly)serositis (13.7%). Multivariate analysis identified prior acute GVHD (odds ratio [OR], 2.28 2.93) infusion donor lymphocytes (OR, 1.77 both) factors classic whereas body irradiation an independent factor 1.76). Compared without those with NIH-defined showed similarly better overall (P = .034 < .001) low relapse-related .001 both). NRM significantly increased GVHD, but not .019 .10), which driven few organ (eg, renal, restrictive lung disease, peripheral neuropathy), others did contribute thyroid gland, musculoskeletal, pancreas). In summary, more common than previously estimated has both similarities differences from particular, subset point urgent need capture cohorts, including treatment outcomes.