The International Association for the Study of Lung Cancer Lung Cancer Staging Project: Proposals for the Revisions of the T-Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Lung Cancer

• DOI: 10.1016/j.jtho.2023.12.006
• Publication Date: 2023-12-07T17:18:57Z
• Authors: Paul E. Van Schil; Hisao Asamura; Katherine K. Nish...; Ramon Rami-Porta; Young Tae Kim; Pietro Bertoglio; Ayten K. Cangir; Jessica Donington; Wentao Fang; Dorothy J. Giroux; Yolande Lievens; Hui Liu; Gustavo Lyons; Shuji Sakai; William D. Travis; Paula Ugalde; Chi-Fu Jeffrey Yang; Masaya Yotsukura; Frank Detterbeck
• Keywords: Male; Lung Neoplasms; Humans; Female; Human medicine; Middle Aged; Neoplasm Staging; Aged

An international database was created by the International Association for the Study of Lung Cancer to inform on the ninth edition of the TNM classification of lung cancer. The present analyses concern its T component.Data on 124,581 patients diagnosed with lung cancer from January 1, 2011 to December 31, 2019 were submitted to the International Association for the Study of Lung Cancer database. Of these, 33,982 met the inclusion criteria for the clinical T analysis, and 30,715 met the inclusion criteria for the pathologic postsurgical analysis. Survival was measured from the date of diagnosis or operation for clinically and pathologically staged tumors, respectively. T descriptors were evaluated in univariate analysis and multivariable Cox regression analysis adjusted for age, sex, pathologic type, and geographic region.Comprehensive survival analysis revealed that the existing eighth edition T component criteria performed adequately in the ninth edition data set. Although pathologic chest wall or parietal pleura involvement (PL 3) yielded a worse survival compared with the other T3 descriptors, with a similar survival as T4 tumors, this difference was not observed for clinical chest wall or PL 3 tumors. Because of these inconsistent findings, no reallocation of chest wall or PL 3 tumors is advised.The T subcommittee members proposed not to implement any changes and keep the current eighth-edition T descriptors for the ninth edition.