1800 RETROPERITONEAL LYMPH NODE METASTASIS IN M0 RENAL CELL CARCINOMA

• DOI: 10.1016/j.juro.2010.02.1724
• Publication Date: 2010-03-23T10:32:53Z
• Authors: Scott Delacroix Jr; Stephen Culp; Jaclyn Jin-Ling Chen; Tamboli Pheroze; Surena Matin; Christopher Wood
• Keywords: Chromophobe cell; Systemic therapy

You have accessJournal of UrologyKidney Cancer: Advanced II1 Apr 20101800 RETROPERITONEAL LYMPH NODE METASTASIS IN M0 RENAL CELL CARCINOMA Scott Delacroix Jr, Stephen Culp, Jaclyn Jin-Ling Chen, Tamboli Pheroze, Surena Matin, and Christopher Wood JrScott Jr More articles by this author , CulpStephen Culp ChenJaclyn Chen PherozeTamboli Pheroze MatinSurena Matin WoodChristopher View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1724AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Patients with renal cell carcinoma retroperitoneal lymph node only metastasis represent a heterogeneous population for which limited prognostic data exists. Delineation factors predicting survival as well analysis outcomes in the cohort would aid deciding between upfront systemic therapy or surgical treatment. METHODS Using M.D. Anderson Cancer Center nephrectomy database, patients without clinical evidence distant (M0) but pathologic positive nodes (Tany,N1-2,M0) were selected. The was analyzed predictive recurrence free (RFS) overall (OS). Recovery from surgery also assessed determine if operative disability preclude those that recurred. RESULTS aforementioned criteria, 69 identified. Histologic diagnosis included clear (47), papillary (12), unclassified (7), chromophobe RCC (3). (OS) TanyN+M0 26.0 months (95% CI:17.7-49.7) median follow up 19.2 (range, 0.3-103.9). For entire cohort, RFS 6.2 total 54 (75.4%) having after resection. Time within first 4 31 (44.9%), 12 8 (11.5%), greater than twelve 13 (18.8%), 17 (24.6%) remained disease long term(median f/u 4.4 years). Predictors presence sarcomatoid features (HR 2.07-univariate), histology 1.63-univariate), number nodes(HR 6.56), Fuhrman grade 2.77), matted 6.93). OS 3.23-univariate), density 1.01), 2.22), 1.09). Clinical status removed did not predict either RFS. Most patients, 60/69 (86.9%), maintained their functional able receive upon recurrence. Rapid decline precluding occurred 6 (8.8%) early progressive disease. Mortality prior hospital discharge 3 (4.3%). CONCLUSIONS isolated metastasis, majority (56.6%) recur year while significant percentage (43.4%) will be surgically cured 1 probably derive benefit therapy. In most resection use Houston, TX© 2010 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e698 Advertisement Copyright & Permissions© Inc.MetricsAuthor Information Expand PDF DownloadLoading ...