Impact of Multiparametric Endorectal Coil Prostate Magnetic Resonance Imaging on Disease Reclassification Among Active Surveillance Candidates: A Prospective Cohort Study

• DOI: 10.1016/j.juro.2011.11.112
• Publication Date: 2012-02-14T11:32:37Z
• Authors: David Margel; Stanley A. Yap; Nathan Lawrentschuk; Laurence Klotz; Masoom Haider; Karen Hersey; Antonio Finelli; Alexandre Zlotta; John Trachtenberg; Neil Fleshner
• Keywords: Cohort Studies; Male; 03 medical and health sciences; 0302 clinical medicine; Population Surveillance; Humans; Prostatic Neoplasms; Prospective Studies; Middle Aged; Magnetic Resonance Imaging; 3. Good health

We report magnetic resonance imaging findings among unselected men with low risk prostate cancer before active surveillance.We prospectively enrolled grade, risk, localized cancer. All patients underwent multiparametric endorectal coil and were offered confirmatory biopsy within 1 year of imaging. The primary outcome was the impact on identifying who reclassified by as no longer fulfilling surveillance criteria. further identified clinical parameters associated reclassification. cohort stratified 1) normal imaging, 2) concordant initial (less than cm) 3) larger cm. performed univariate analysis to assess differences in groups.Magnetic did not detect 23 cases (38%) while 24 (40%). Magnetic detected a cm or lesion 13 (22%). Of 18 (32.14%) reclassified. When only 2 (3.5%) positive negative predictive values for predicting reclassification 83% (95% CI 73-93) 81% 71-91), respectively. Prostate specific antigen density increased lesions compared those (median 0.15 vs 0.07 ng/ml/cc, p=0.016).Magnetic appears have high yield elect surveillance. Upon confirmation our results may be used better select guide