Multiparametric Ultrasound of the Prostate: Adding Contrast Enhanced Ultrasound to Real-Time Elastography to Detect Histopathologically Confirmed Cancer

• DOI: 10.1016/j.juro.2012.08.183
• Publication Date: 2012-11-16T11:51:54Z
• Authors: Marko Brock; Thilo Eggert; Rein Jüri Palisaar; Florian Roghmann; Katharina Braun; Björn Löppenberg; Florian Sommerer; Joachim Noldus; Christian von Bodman
• Keywords: Ultrasound Elastography; Contrast-enhanced ultrasound; Cancer Detection

We prospectively assessed whether a combined approach of real-time elastography and contrast enhanced ultrasound would improve prostate cancer visualization.Between June 2011 January 2012, 100 patients with biopsy proven underwent preoperative transrectal multiparametric combining ultrasound. After initial elastographic screening for suspicious lesions, defined as blue areas decreased tissue strain, each lesion was allocated to the corresponding sector. The target largest area. Perfusion monitored after intravenous injection agent. Target lesions were examined hypoperfusion, normoperfusion or hyperperfusion. Imaging results correlated final pathological evaluation on whole mount slides radical prostatectomy.Of 86 eligible analysis. Real-time detected 49% sensitivity 73.6% specificity. Histopathology confirmed malignancy in 56 (65.1%). Of these 52 (92.9%) showed perfusion, including hypoperfusion 48.2% hyperperfusion 48.2%, while only 4 (7.1%) normal perfusion patterns (p = 0.001). false-positive value alone from 34.9% 10.3% improved positive predictive detection 65.1% 89.7%.Perfusion are heterogeneous. However, this pilot study significantly correctly identifying histopathological cancer.