Kidney disease in the setting of HIV infection: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

• DOI: 10.1016/j.kint.2017.11.007
• Publication Date: 2018-02-03T03:07:59Z
• Authors: Charles R. Swanepoel; Mohamed G. Atta; Vivette D. D’Agati; Michelle M. Estrella; Agnes B. Fogo; Saraladevi Naicker; Frank A. Post; Nicola Wearne; Cheryl A. Winkler; Michael Cheung; David C. Wheeler; Wolfgang C. Winke...; Christina M. Wyatt; Ali Abu-Alfa; Dwomoa Adu; Lawrence Y. Agodoa; Charles E. Alpers; Fatiu A. Arogundade; Gloria Ashuntantang; Corinne I. Bagnis; Raj Bhimma; Isabelle Brocheriou; Arthur H. Cohen; Karen Cohen; H. Terence Cook; Sophie de Seigneux; June Fabian; Fredric O. Finkel...; Mark Haas; Lisa Hamzah; Bruce M. Hendry; Valentine Imonje; J. Charles Jennette; Paul L. Kimmel; Mary E. Klotman; Paul E. Klotman; Chris P. Larsen; Mignon I. McCulloch; Pulane Mosiane; Cynthia C. Nast; Ikechi G. Okpechi; Patricio E. Ray; Avi Z. Rosenberg; Michael J. Ross; Lene Ryom; Luan Truong; Ifeoma Ulasi; Liffert Vogt; Martin Zeier
• Keywords: Kidney Disease; Conference Participants; HIV/drug effects/genetics/pathogenicity; Kidney/drug effects/pathology/virology; Comorbidity; Kidney; podocytopathy; 0302 clinical medicine; Risk Factors; Diagnosis; 2.1 Biological and endogenous factors; Renal Insufficiency; Aetiology; Chronic; APOL1; Pediatric; immune complex kidney disease; Evidence-Based Medicine; Evidence-Based Medicine/standards; Urology & Nephrology; 3. Good health; Infectious Diseases; Treatment Outcome; Nephrology; 6.1 Pharmaceuticals; AIDS-Associated Nephropathy/diagnosis/epidemiology/genetics/therapy; Host-Pathogen Interactions; Nephrology/standards; HIV/AIDS; Infection; Anti-HIV Agents; CKD progression; antiretroviral therapy; Clinical Sciences; Renal and urogenital; Diagnosis, Differential; 03 medical and health sciences; renal pathology; Predictive Value of Tests; Renal Insufficiency, Chronic/diagnosis/epidemiology/genetics/therapy; 616; Humans; Genetic Predisposition to Disease; AIDS-Associated Nephropathy; Renal Insufficiency, Chronic; Prevention; Evaluation of treatments and therapeutic interventions; HIV; Good Health and Well Being; Differential; Anti-HIV Agents/adverse effects

HIV-positive individuals are at increased risk for kidney disease, including HIV-associated nephropathy, noncollapsing focal segmental glomerulosclerosis, immune-complex and comorbid as well injury resulting from prolonged exposure to antiretroviral therapy or opportunistic infections. Clinical guidelines disease prevention treatment in largely extrapolated studies the general population, do not fully incorporate existing knowledge of unique HIV-related pathways genetic factors that contribute this population. We convened an international panel experts nephrology, renal pathology, infectious diseases define pathology setting HIV infection; describe role genetics natural history, diagnosis, individuals; characterize risk-benefit prevention; best practices management individuals.