Prevalence of prediabetes in Mexico: a retrospective analysis of nationally representative surveys spanning 2016–2022

• DOI: 10.1016/j.lana.2023.100640
• Publication Date: 2023-11-24T17:53:56Z
• Authors: Carlos A. Fermín-...; César Daniel Paz-...; Martín Roberto Ba...; Paulina Sánchez C...; Alejandra Núñez-Luna; Jerónimo Perezalo...; Daniel Ramírez-Ga...; Neftali Eduardo A...; Arsenio Vargas-Vá...; Luisa Fernández-C...; Karime Berenice C...; Leslie Alitzel Ca...; Rosalba Rojas-Mar...; Jacqueline A. Sei...; Omar Yaxmehen Bel...
• Keywords: Prediabetes; Impaired fasting glucose; Cross-sectional study

Characterizing prediabetes phenotypes may be useful in guiding diabetes prevention efforts; however, heterogeneous criteria to define have led inconsistent prevalence estimates, particularly low- and middle-income countries. Here, we estimated trends Mexico across different definitions their association with prevalent cardiometabolic conditions.We conducted a serial cross-sectional analysis of National Health Nutrition Surveys (2016-2022), totalling 22 081 Mexican adults. After excluding individuals diagnosed or undiagnosed diabetes, defined using ADA (impaired fasting glucose [IFG] 100-125 mg/dL and/or HbA1c 5.7-6.4%), WHO (IFG 110-125 mg/dL), IEC (HbA1c 6.0-6.4%). Prevalence over time were evaluated weighted Poisson regression its conditions logistic regression.The (either IFG high [ADA]) was 20.9% 2022. Despite an overall downward trend (RR 0.973, 95% CI 0.957-0.988), this primarily driven by decreases ADA-IFG 0.898, 0.880-0.917) WHO-IFG 0.919, 0.886-0.953), while ADA-HbA1c 1.055, 1.033-1.077) IEC-HbA1C 1.085, 1.045-1.126) increased time. Prediabetes adults >40 years, central obesity, self-identified as indigenous living urban areas. For all definitions, associated risk conditions.Prediabetes rates from 2016 2022 varied based on defining but consistently for HbA1c-based high-risk subgroups.This research supported Instituto Nacional de Geriatría Mexico. JAS NIH/NIDDK Grant# K23DK135798.