The changing pattern of enteric pathogen infections in China during the COVID-19 pandemic: a nation-wide observational study

• DOI: 10.1016/j.lanwpc.2021.100268
• Publication Date: 2021-09-20T08:02:03Z
• Authors: Li-Ping Wang; Jia-Yi Han; Shi-Xia Zhou; Lin-Jie Yu; Qing-Bin Lu; Xiao-Ai Zhang; Hai-Yang Zhang; Xiang Ren; Cui-Hong Zhang; Yi-Fei Wang; Sheng-Hong Lin; Qiang Xu; Bao-Gui Jiang; Chen-Long Lv; Jin-Jin Chen; Chang-Jun Li; Zhong-Jie Li; Yang Yang; Wei Liu; Li-Qun Fang; Simon I. Hay; George F. Gao; Wei-Zhong Yang
• Keywords: Pandemic; Coronavirus

Non pharmaceutical interventions (NPI) including hand washing directives were implemented in China and worldwide to combat the COVID-19 pandemic, which are likely have had impacted a broad spectrum of enteric pathogen infections.Etiologically diagnostic data from 45 937 67 395 patients with acute diarrhea between 2012 2020, who tested for seven viral pathogens 13 bacteria respectively, analyzed assess changes infections during first pandemic year compared pre-pandemic years.Test positive rates all viruses decreased average levels 2012-2019, relative decrease 71•75% adenovirus, 58•76% norovirus, 53•50% rotavirus A, 72•07% combination other four uncommon viruses. In general, larger reduction rate was seen among adults than pediatric patients. A rebound after September 2020 North rather South China. Test excepting nontyphoidal Salmonella Campylobacter coli 66•53% 90•48% increase respectively. This adult patients.The activity changed profoundly alongside NPIs Greater reductions test found almost patients, further large differences by age geography. Lifting will lead resurgence infections, particularly children whose immunity may not been developed and/or waned.China Mega-Project on Infectious Disease Prevention; National Natural Science Funds.