Reply to author: “uric acid's influence on venous thromboembolism in East Asia”

• DOI: 10.1016/j.lanwpc.2023.100915
• Publication Date: 2023-09-21T16:52:55Z
• Authors: Haobo Li; Zhu Zhang; Haoyi Weng; Wanmu Xie; Peiran Yang; Zhenguo Zhai; Chen Wang
• Keywords: Mendelian Randomization

We appreciate the insightful comments and commendations expressed by Lixian Ji Peng Shu regarding our study titled "Association between uric acid risk of venous thromboembolism in East Asian populations: a cohort Mendelian randomization study".1Weng H. Li Zhang Z. et al.Association study.Lancet Reg Health West Pac. 2023; 39100848PubMed Google Scholar Their supportive remarks have both encouraged team reaffirmed importance research within broader scientific discourse.2Ji L. P. Letter to editor: study".Lancet 39100848Google would like address specific points raised as follows:1.Regarding PE VTE distinction: acknowledge this oversight agree that it is crucial specify primarily focused on pulmonary embolism (PE) or with deep vein thrombosis (DVT).3Zhang Weng al.Genome-wide association analyses identified novel susceptibility loci for among Han Chinese population.BMC Med. 21: 153Crossref PubMed Scopus (3) Scholar,4Zhai Wang D. Lei J. al.Trends stratification, in-hospital management mortality patients acute embolism: an analysis from China pUlmonary REgistry Study (CURES).Eur Respir 2021; 582002963Crossref (14) By providing clarification, we can prevent potential misconceptions ensure implications findings are appropriately understood relevant context.2.On instrumental variable clumping process: It should be noted similar GWAS studies, there currently no standardized criterion determining appropriate thresholds (MR) research. The selection contingent upon circumstances study. In study, employed slightly relaxed retain greater number variables (IVs), thereby enhancing statistical power Notably, previous studies demonstrated incorporating multiple weakly correlated variants IVs explain larger proportion variance factor, strengthening MR analysis.5Burgess S. Davey Smith G. Davies N.M. al.Guidelines performing investigations: update summer 2023.Wellcome Open Res. 4: 186https://doi.org/10.12688/wellcomeopenres.15555.3Crossref Scholar,6Burgess Frank Thompson S.G. "Combining information randomization: comparison allele score summarized data methods.".Stat 2016; 35: 1880-1906Crossref However, essential consequences weak linkage disequilibrium (LD), utilized analysis, which associated causal variant, may influence other confounding factors. That lead violations second third IV assumptions, akin pleiotropy-induced violations. To concern, multivariate conducted tests pleiotropy reduce bias. Moreover, performed leave-one-out exclusion any individual did not significantly impact results.3.Incorporation smoking history covariate: suggestion concur might indeed significant confounder.7Larsson S.C. Mason A.M. Bäck M. al.Genetic predisposition relation 14 cardiovascular diseases.Eur Heart 2020; 41: 3304-3310Crossref (61) Due limitations available data, were unable include covariate analysis. Nonetheless, its intend consider future investigations analyses. light constructive feedback provided, committed further exploring these areas more comprehensive subsequent publications. Collaborative discussions, such this, only enhance quality rigor but also contribute holistic understanding complex medical phenomena. eagerly anticipate collaborations discussions peers field. Together, continually refine methodologies share insights, strive towards deeper comprehension serum levels, ultimately benefiting populations worldwide. Haobo Li, Zhu Zhang, Haoyi wrote reply. Wanmu Xie, Peiran Yang, Zhenguo Zhai, Chen reviewed edited authors conflicts interest declare. This was funded Beijing Nova Program (No. Z211100002121057), National Natural Science Foundation 82100065 No. 62350004), CAMS Innovation Fund Medical Sciences (2021-I2M-1-061, 2021-I2M-1-049, 2021-1-I2M-001), High Level Hospital Clinical Research Funding (2022-NHLHCRF-LX-01-0203), Elite Professionals project China-Japan Friendship ZRJY2021-QM12), Key Development Project 2021YFF1201200 2022YFC3341004). funders had role design, collection interpretation, writing report. "uric acid's Asia"To Editor: Full-Text PDF AccessAssociation studyOur provides evidence supporting robust positive SUA population, suggest likely causal. Our underscore monitoring levels prevention call urgent action growing burden hyperuricemia Asia-Pacific region. Access