A possible association between low MBL/lectin pathway functionality and microbiota dysbiosis in endometriosis patients

• DOI: 10.1016/j.lfs.2025.123427
• Publication Date: 2025-01-30T07:59:15Z
• Authors: Miriam Toffoli; Giuseppina Campis...; Aurora Santin; Silvia Pegoraro; Gabriella Zito; Beatrice Spedicati; Andrea Balduit; Federico Romano; Giovanni Di Lorenzo; Alessandro Mangogna; Paola Tesolin; Giuseppe Giovanni...; Nunzia Zanotta; Serena Sanna; Francesca Crobu; Uday Kishore; Giuseppe Ricci; Roberta Bulla; Giorgia Girotto; Chiara Agostinis
• Keywords: Dysbiosis

Endometriosis (EM) is a chronic inflammatory disorder with multifactorial etiologies (i.e., genetics and environmental factors, hormonal immunological changes, microbiome alterations). The complement system one of the most frequently dysregulated pathways in EM. Mannose-binding lectin (MBL), carbohydrate pattern recognition molecule, first described subcomponent pathway (LP). Here, we unveiled interplay among MBL polymorphisms, plasma levels, LP functionality, microbiota as potential contributors to EM pathogenesis. A cohort 38 patients 20 healthy controls was enrolled levels functionality were assessed via ELISA assays. genetic variants endometrial vaginal investigated correlated. High related disease severity, although not accountable MBL2 genotype. MASP-2 present uterine mucosa but appeared have no function at endometriotic lesion. functional deficit displayed pathogenic bacterial species more microbiome. Moreover, women affected by showed higher frequency rare gene estrogen genes, potentially affecting levels. lower may contribute an unbalanced environment that could activate cells. Not only genotype condition, also can cause altered thus contributing changes functionality.