Common and distinct metabolomic markers related to immune aging in Western European and East African populations

• DOI: 10.1016/j.mad.2024.111916
• Publication Date: 2024-02-14T09:39:49Z
• Authors: Ozlem Bulut; Godfrey S. Temba; Valerie A.C.M. Ko...; Simone J.C.F.M. M...; L. Charlotte J. d...; Vera P. Mourits; Vesla I. Kullaya; Martin Jaeger; Cancan Qi; Niels P. Riksen; Jorge Domínguez-A...; Cheng-Jian Xu; Leo A.B. Joosten; Yang Li; Quirijn de Mast; Mihai G. Netea
• Keywords: Immunosenescence; Senescence

In old age, impaired immunity causes high susceptibility to infections and cancer, higher morbidity mortality, poorer vaccination efficiency. Many factors, such as genetics, diet, lifestyle, impact aging. This study aimed investigate how immune responses change with age in healthy Dutch Tanzanian individuals identify common metabolites associated an aged profile. We performed untargeted metabolomics from plasma age-associated metabolites, we correlated their concentrations ex-vivo cytokine production by cells, DNA methylation-based epigenetic aging, telomere length. Innate were impacted differently cohorts. Age-related decline steroid hormone precursors both populations was systemic inflammation lower responses. Hippurate 2-phenylacetamide, commonly more abundant older individuals, negatively length positively Lastly, identified several that might contribute the stronger innate Tanzanians. The shared metabolomic signatures of two cohorts suggest mechanisms revealing potential contributions. These findings also reflect genetic or environmental effects on circulating modulate