Application of synthetic and natural polymers in surgical mesh for pelvic floor reconstruction

• DOI: 10.1016/j.matdes.2021.109984
• Publication Date: 2021-07-16T05:06:16Z
• Authors: Mengqin Yuan; Min Hu; Fangfang Dai; Yaqi Fan; Zhimin Deng; Hongbing Deng; Yanxiang Cheng
• Keywords: Biocompatibility; Surgical mesh; Pelvic Floor Dysfunction

Pelvic floor dysfunction (PFD) is a common gynecological problem that affects millions of women. Current treatment strategies are to restore the normal anatomical structure by non-operative procedures (such as pelvic myoelectric stimulation) or surgery vaginal mesh implantation). Although meshes can provide effective, long-term and minimally invasive for patients, certain life-altering complications may occur. Physical characteristics porosity, weight mechanical properties), manufacturing process material type parameters greatly influence cell attachment, tissue proliferation regeneration. The best clinical effectiveness surgical could be obtained optimizing these parameters. Material has particularly important on strength, biodegradation rate biocompatibility implants. Therefore, selection crucial development an ideal repair use in reconstruction. materials suitable have been broadly classified into three groups, which synthetic polymers, natural polymers polymer blends. This review mainly focuses application biological blends engineering.