Construction and function of robust and moist bilayer chitosan-based hydrogel wound dressing

• DOI: 10.1016/j.matdes.2023.111604
• Publication Date: 2023-01-06T16:23:51Z
• Authors: Jiawei Lu; Xiaokun Fan; Jiawei Hu; Jie Li; Jingjing Rong; Weijia Wang; Ying Chen; Wenyong Liu; Jin Chen; Yi Chen
• Keywords: Vinyl alcohol; Wound dressing; Brittleness; Polyacrylamide; Wound Closure

The main limit of hydrogel used as an independent wound dressing is its poor water retention, brittleness, and weak skin adhesion. Focusing on it, the macromolecular cross-linked chitosan polyacrylamide double network (C-A) chosen a functional layer, another robust poly(vinyl alcohol)-polyacrylamide/glycerin (P-A) protective layer designed to cover surface, interfacial reaction happens link two layers tightly for achieving function synergy. In this double-layer (DH) dressing, surface P-A with strong locking ability could keep moist long time, high strength toughness make maintain integrity under large deformation stress strengthen protection, C-A modest adhesion ensures fit skin, synergistic swelling guarantee fast absorption exudate. Moreover, in vitro vivo tests, DH exhibits excellent antibacterial cytocompatibility, it significantly accelerate tissue regeneration closure than commercial hydrocolloid dressings. general, easy prepare shows superior comprehensive performance, revealing great potential use independently applied dressing.