Antimicrobial peptide nanoparticles coated with macrophage cell membrane for targeted antimicrobial therapy of sepsis

• DOI: 10.1016/j.matdes.2023.111883
• Publication Date: 2023-03-30T01:04:13Z
• Authors: Zhizhen Meng; Luqi Pan; Songzan Qian; Xiao Yang; Lingling Pan; Runrun Chi; Jie Chen; Jingye Pan; Changcan Shi
• Keywords: 0301 basic medicine; 03 medical and health sciences; Macrophage membrane; Sepsis; Target delivery; TA401-492; Nanoparticles; Bacterial infection; Antimicrobial peptide; Materials of engineering and construction. Mechanics of materials

Sepsis is a serious life-threatening disease. Bacterial infection one of the main causes sepsis. Although etiopathogenesis gradually understood, treatment still scarce. Mortality caused by sepsis challenge. Herein, macrophage membrane coated antimicrobial peptide nanoparticles (M−AMPNP) was explored based on specific binding bacterial recognition receptors to bacteria. M−AMPNP used treat infection. In vivo results showed that effectively delivered and retained at site intravenous injection, which reduced level inflammatory factors ultimately gave infected mice significant survival advantage. provides potential strategy for targeted therapy