Dynamic dual-crosslinking antibacterial hydrogel with enhanced bio-adhesion and self-healing activities for rapid hemostasis in vitro and in vivo

• DOI: 10.1016/j.matdes.2023.112244
• Publication Date: 2023-08-12T20:37:43Z
• Authors: Ranran Si; Yifan Wang; Yuchun Yang; Ansar Javeed; Jianing Chen; Bingnan Han
• Keywords: Biocompatibility; Vinyl alcohol; Fibroin

Bio-adhesives based on natural polymer silk fibroin (SF) are high-profiled in the development of rapid hemostatic agents because their good biocompatibility and biodegradability. However, lack bioactivity, mechanical bio-adhesion performance, restrict use biomedical field. Herein, dynamic dual-crosslinking mechanism, we fabricated a microfibers (SMFs)-based multifunctional hydrogel by incorporating tannic acid-coated SMF (TA@SMF) motifs into network poly(vinyl alcohol)-borax (PB) hydrogel. The cohesion-enhancing strategy, along with borate-diol bonds hydrogen bonds, synergically provide enhanced self-healing properties. TA@SMF/PB gel has an elongation at break more than 600% adheres to pig skin even after 24 h immersion water. In vitro experiments have shown antibacterial, antioxidant, biocompatibility, properties gel. vivo degradation mouse liver test further verified its biosafety hemostasis performance. time 42.0 ± 4.9 s [email protected] was significantly shorter that other experimental groups. This study is original report for functionalizing SMFs TA as material, which affords versatile SMF-based toolkit provides promising candidate materials infectious wound healing.