Hydrogels with brain tissue-like mechanical properties in complex environments

• DOI: 10.1016/j.matdes.2023.112338
• Publication Date: 2023-09-21T00:54:34Z
• Authors: Jingyu Wang; Yongrou Zhang; Zuyue Lei; Junqi Wang; Yangming Zhao; Taolin Sun; Zhenyu Jiang; Licheng Zhou; Zejia Liu; Yiping Liu; Bao Yang; Liqun Tang
• Keywords: Brain tissue

In surgical training and experimental research, brain tissues immersed in cerebrospinal fluid often exhibit complex deformation strain rate effects that can compromise their reliability stability. Therefore, it is essential to develop a high-fidelity human tissue simulant material serves as physical surrogate model understand its mechanical behavior, such traumatic injury (TBI). However, the existing materials have failed meet required properties. This study presents composite hydrogel consisting of both rigid polysaccharides network (Sodium alginate Pectin) flexible polyacrylamide network, exhibiting tissue-like properties under various solution environments rates. The results show nonlinear behavior good similarity external (artificial fluid, normal saline, deionized water, air environments) different rates (0.001 s−1,900 s−1,1700 s−1). By analyzing data theoretical analysis, we examine on porcine tissue. Given resemble those tissue, our work has significant reference value realizing advancing related research biomedical engineering.