A novel natural polysaccharide dissolving microneedle capable of adsorbing pus to load EGCG for the treatment of acne vulgaris

• DOI: 10.1016/j.matdes.2024.112639
• Publication Date: 2024-01-08T16:35:46Z
• Authors: Junbo Zhang; Peng Guo; Mengyu Qiu; Guofeng Zhong; Qin Yang; Pengkun Lei; Kaijun Gou; Rui Zeng; Chen Zhang; Yan Qu
• Keywords: Propionibacterium Acnes

Acne vulgaris is a common inflammatory skin disease associated with Propionibacterium acnes (P. acnes), serious physical and psychological effects on patients. Conventional topical use of antibiotics not effective due to the barrier oral administration can adversely affect intestinal flora. Microneedle novel type localized drug delivery system that noninvasively breaks through stratum corneum effectively enhances transdermal absorption drugs. Here, Bletilla striata polysaccharide (BSP)/Hyaluronic acid (HA) loaded Epigallocatechin gallate (EGCG) was used as microneedle body easily penetrate epidermis enhance antibacterial ability. Polyvinyl alcohol (PVA) Diatomaceous earth (DE) are backing absorb pus bacterial debris, prevent re-infection bacteria promote healing. Compared traditional antibiotics, excellent permeability EGCG @ BSP/ HA MNs studied here improve efficacy solve side resistance. In vivo studies in mice models induced by P. showed this could reduce swelling, inhibit growth levels TNF-α, IL-8 MMP-2. summary, study provides an ideal antimicrobial for treatment acne vulgaris.