A green route to synthesis silver nanoparticles using Sargassum polycystum and its antioxidant and cytotoxic effects: An in vitro analysis

• DOI: 10.1016/j.matlet.2016.12.005
• Publication Date: 2016-12-05T01:45:58Z
• Authors: Subramanian Palan...; Periyannan Rajasekar; Gandhi Vijayaprasath; Ganesan Ravi; Ramar Manikandan; Narayanan Marimut...
• Keywords: Phytochemical; Silver nanoparticle; IC50; MTT assay

Abstract The aim of the present study is to find out a biocompatible silver nanoparticles synthesized from Sargassum polycystum for antioxidant and anticancer activity. The phytochemical constituent was investigated by standard method and it possesses alkaloids, flavanoids, steroids, terpenoids, protein, amino acids, carbohydrate, quinones, phenols and tannins. The synthesized AgNPs were characterized by various spectroscopic and microscopic techniques. Interestingly, AgNPs exhibit highest level of DPPH radical scavenging (78.2% of inhibition), reducing power (0.18±0.006) and total antioxidant activities (59.2±0.54%) when compared to crude extract. IC 50 value of AgNPs was 20 µg/ml against human colon cancer (HT-29) cells through in vitro cytotoxicity assay and the activity was proportionate to the concentration of AgNPs. Thus the present finding confirms that the synthesized AgNPs possess antioxidant and anticancer properties.