Anticancer and antioxidant activities of Cyphostemma auriculatum Roxb. green mediated silver nanoparticles

• DOI: 10.1016/j.matpr.2023.04.126
• Publication Date: 2023-04-20T13:29:43Z
• Authors: Kishore Mendam; S. Jithender Kuma...
• Keywords: ABTS; Silver nanoparticle; Monoclinic crystal system

The aim of this study was to evaluate the anticancer and antioxidant effect Silver nanoparticles synthesized from extract Cyphostemma auriculatum Roxb. absorption peak with highest intensity determined at a wavelength 409 nm employing UV–visible spectrophotometry. In accordance FTIR spectrum, Roxb relies significantly on proteins for its stability. crystalline structure CA-AgNPs is characterised by X-Ray Diffraction (XRD) peaks 2 theta values 37.81, 45.93, 64.36, 77.25, which correlate lattice planes (1 1 1), (2 0 0), (3 1) face-centric cubic structure.Transmission electron microscope (TEM) analysis indicates about have orbicular in shape, are uniformly dispersed, possess monoclinic crystal structure; their average surface diameter 15 nm. feature rough as seen using scanning (SEM).The cytotoxicity biogenic silver derived plant (CA-AgNPs) work 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) test.The results were positive. Various concentration (µg) 10, 20, 40, 60, 80 100 µg/mL showed % viabilities 98, 88, 80, 72, 49 33% respectively IC50 value 70.40 µg/mL. 2,2-diphenyl-1-picrylhydrazyl (DPPH) 2,2′-Azinobis [3-ethylbenzothiazoline-6-sulfonic acid] (ABTS) tests used scavenging activity these AgNPs. At µg/mL, maximum tested, 95% DPPH scavenging% 98.5 ABTS observed. These AgNPs' capabilities found be effective. formula derive 55.66 activity. AgNPs 25.77 tested (100 g/mL). This suggests that Roxb.-mediated show promise clinically effective agent virtue ability lower oxidative stress cancer patients.