A Framework for Outpatient Infusion of Antispike Monoclonal Antibodies to High-Risk Patients with Mild-to-Moderate Coronavirus Disease-19

• DOI: 10.1016/j.mayocp.2021.03.010
• Publication Date: 2021-03-09T21:33:21Z
• Authors: Raymund R. Razonable; Nicole C.E. Aloia; Ryan J. Anderson; Gokhan Anil; Lori L. Arndt; Richard F. Arndt; Sara E. Ausman; Sarah J. Bell; Dennis M. Bierle; Marcie L. Billings; Rachel K. Bishop; Carl H. Cramer; Tracy L. Culbertson; Ala S. Dababneh; Amber N. Derr; Kevin Epps; Susan M. Flaker; Ravindra Ganesh; Mary A. Gilmer; Eric Gomez Urena; Christopher R. Gu...; Tamara L. Haack; Sara N. Hanson; Jenna R. Herzog; Alexander Heyliger; Lex D. Hokanson; Laura H. Hopkins; Richard J. Horecki; Bipinchandra Hiri...; W. Charles Huskins; Tammy A. Jackson; Ryan R. Johnson; Betty Jorgenson; Cory Kudrna; Brian D. Kennedy; Mary K. Klingsporn; Brian Kottke; Jennifer J. Larsen; Sarah R. Lessard; Larry I. Lutwick; Edward J. Malone; Jennifer A. Matoush; Ivana N. Micallef; Darcie E. Moehnke; Muhanad Mohamed; Colleena N. Ness; Shelly M. Olson; Robert Orenstein; Raj Palraj; Janki Patel; Damian J. Paulson; David Phelan; Margaret T. Peino...; Wilford L. Ramsey; Taunya J. Rau-Kane; Kevin I. Reid; Karen J. Reinschmidt; Maria Teresa Seville; Erin C. Skold; Jill M. Smith; Leigh L. Speicher; Laurie A. Spielman; Donna J. Springer; Perry W. Sweeten; Jennifer M. Tempelis; Sidna Tulledge-Sc...; Paschalis Vergidis; Daniel C. Whipple; Caroline G. Wilker; Molly J. Destro B...
• Keywords: SARS-CoV-2; Antibodies, Monoclonal; COVID-19; Efficiency, Organizational; Antiviral Agents; Organizational Culture; Severity of Illness Index; United States; 3. Good health; Special Article; 03 medical and health sciences; 0302 clinical medicine; Clinical Protocols; Spike Glycoprotein, Coronavirus; Critical Pathways; Humans; Program Development; Intersectoral Collaboration; Home Infusion Therapy

The administration of spike monoclonal antibody treatment to patients with mild moderate COVID-19 is very challenging. This article summarizes essential components and processes in establishing an effective infusion program. Rapid identification a dedicated physical infrastructure was circumvent the logistical challenges caring for infectious while maintaining compliance regulations ensuring safety our personnel other patients. Our partnerships collaborations among multiple different specialties disciplines enabled contributions from specific expertise medicine, nursing, pharmacy, infection prevention control, electronic health record (EHR) informatics, compliance, legal, medical ethics, engineering, administration, critical areas. Clear communication culture which all roles are welcomed at planning operational tables rapid development refinement needed adapt thrive providing this time-sensitive beneficial therapy. leaders providers outside institutions, including those who care underserved populations, have promoted equity access antibodies regions. Strong support institutional leadership facilitated expedited action when needed, physical, personnel, system standpoint. ongoing real-time assessment monitoring clinical program allowed us improve optimize ensure that needs outpatient setting met.