Robust and Versatile Cu(I) metal frameworks as potential catalysts for azide-alkyne cycloaddition reactions: Review

• DOI: 10.1016/j.mcat.2021.111432
• Publication Date: 2021-02-16T12:22:49Z
• Authors: Parveen Saini; Sonika; Gurjaspreet Singh; Gurpreet Kaur; Jandeep Singh; Harminder Singh
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract The use of ‘Click Reaction’ for Cu(I) catalyzed azide–alkyne cycloaddition (CuAAC) has emerged as one of the most powerful tools for the synthesis of library of organic molecules having a wide range of applications. The approach is highly stereoselective that involves the formation of 1,4–disubstituted 1,2,3–triazole derivatives by the combination of diverse structural entities in the presence of Cu(I) as catalyst. There are numerous synthetic Cu (I) complexes with different ligands bound in diverse molecular framework with potential to act as catalyst to stitch organic azide to alkyne producing 1,4-di-substituted products. This review emphasizes on those versatile Cu (I) complexes having tailoring capability similar to those available commercially.