Immune response dynamics

• DOI: 10.1016/j.mcm.2010.02.040
• Publication Date: 2010-03-08T07:39:05Z
• Authors: N.J. Burroughs; B.M.P.M. Oliveira; A.A. Pinto; M. Ferreira
• Keywords: 0303 health sciences; 03 medical and health sciences; Modelling and Simulation; Computer Science Applications; 3. Good health

The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We determine the analytic formula that describes the fine balance between Regulatory T cells and T cells at controlled and immune response equilibrium states. We demonstrate that cytokine dependent growth exhibits a quorum T cell population threshold that determines if immune responses develop on activation. We determine the analytic formulas of T cell proliferation thresholds that allow us to study the sensibility of the quorum growth thresholds controlling immune responses.