Effect of light transition metal complexes of methanesulfonic acid hydrazide on the viability of yeast Saccharomyces cerevisiae

• DOI: 10.1016/j.mcp.2014.06.004
• Publication Date: 2014-06-25T12:00:44Z
• Authors: George A. Miloshev; Ekaterina N. Peyc...; Nicolay I. Dodoff; Daniel N. Kushev; Maria Lalia-Kantouri
• Keywords: Mesylates; Hydrazines; Time Factors; Dose-Response Relationship, Drug; Molecular Structure; Organometallic Compounds; Transition Elements; Saccharomyces cerevisiae; 01 natural sciences; 0104 chemical sciences

The effect of methanesulfonic acid hydrazide (MSH) and its complexes [M(MSH)4Cl2] (M = Mn, Fe, Co, Ni) and [Zn(MSH)2Cl2] on culture growth suppression and viability (Colony Forming Units) of Saccharomyces cerevisiae has been studied. The highest culture growth suppression was exhibited by [Co(MSH)4Cl2], whereas the most cytotoxic appeared [Mn(MSH)4Cl2]. The changes in cell morphology were also traced by means of FACS analysis.