Sulconazole Induces PANoptosis by Triggering Oxidative Stress and Inhibiting Glycolysis to Increase Radiosensitivity in Esophageal Cancer

• DOI: 10.1016/j.mcpro.2023.100551
• Publication Date: 2023-04-18T00:54:35Z
• Authors: Lu-Xin Liu; Jing-Hua Heng; Dan-Xia Deng; Hui Zhao; Zhen-Yuan Zheng; Lian-Di Liao; Wan Lin; Xiu-E. Xu; En-Min Li; Li-Yan Xu
• Keywords: Radiosensitivity

Esophageal cancer is the seventh most common in world. Although traditional treatment methods such as radiotherapy and chemotherapy have good effects, their side effects drug resistance remain problematic. The repositioning of function provides new ideas for research development anticancer drugs. We previously showed that Food Drug Administration-approved sulconazole can effectively inhibit growth esophageal cells, but its molecular mechanism not clear. Here, our study demonstrated had a broad spectrum effects. It only proliferation also migration cells. Both transcriptomic sequencing proteomic could promote various types programmed cell death glycolysis related pathways. Experimentally, we found induced apoptosis, pyroptosis, necroptosis, ferroptosis. Mechanistically, triggered mitochondrial oxidative stress inhibited glycolysis. Finally, low-dose increase radiosensitivity Taken together, these findings provide strong laboratory evidence clinical application cancer.