The difluoroboranyl-norfloxacin complex “7a” induces an antimicrobial effect against K. pneumoniae strain in acute pneumonia murine model

• DOI: 10.1016/j.medidd.2023.100160
• Publication Date: 2023-08-09T01:53:54Z
• Authors: L. Angel Veyna-Hu...; Hiram Hernández-L...; Fuensanta Reyes-E...; Mitzzy Medellín-Luna; Salvador García-Cruz; Lorena Troncoso-V...; Irma E. González-...; Marisol Galván-Va...; Julio E. Castañed...; Alberto Rafael Ce...
• Keywords: Quinolone

The discovery and implementation of antibiotics led to a better prognosis for infectious diseases. Fluoroquinolones are family with broad spectrum action antibacterial effectiveness. Because bacterial strains have increased their resistance antibiotics, the World Health Organization has reported an urgent need develop new active molecules. Our research group therefore focused on deriving different compounds from fluoroquinolones. A fluoroquinolone derivatized in complex boron, labeled 7a, was found good potential. objective this evaluate vitro vivo antimicrobial effect 7a K. pneumoniae (clinical isolates) strains. Kirby-Bauer inhibition technique generated average areas 8.24±1.239cm2. For minimum inhibitory concentration bactericidal concentration, macrodilutions compound were performed, obtaining 1 μg/mL both determinations. model, Balb/c mice infected intratracheally pneumoniae; animals treated daily ciprofloxacin (80mg/kg/day) or (80mg/kg/day). sacrificed seventh day post-infection hematoxylin eosin staining done lungs percentage pneumonia. It that significantly reduced generation pneumonia (5.96% pneumonic tissue found) while untreated 71.70% lung tissue. Compound is agent capable inhibiting development Gram-negative (K. pneumoniae) strain. In addition, effective treating acute induced by murine model.