A multi-country analysis of COVID-19 hospitalizations by vaccination status
Case fatality rate
Commonwealth
DOI:
10.1016/j.medj.2023.08.005
Publication Date:
2023-09-21T14:28:59Z
AUTHORS (480)
ABSTRACT
BackgroundIndividuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated with regard to presentation, coexisting comorbidities, and outcomes.MethodsHere, we use data an international consortium study this question assess differences between groups are context specific. Data 83,163 COVID-19 (34,843 vaccinated, 48,320 unvaccinated) 38 countries were analyzed.FindingsWhile typical symptoms more often reported in patients, including some associated worse prognosis previous studies, common patients. Considerable between-country variation both in-hospital fatality risk vaccinated-versus-unvaccinated difference outcome was observed.ConclusionsThese findings will inform allocation of healthcare resources future surges as well design longer-term studies characterize changes clinical profile related vaccination history.FundingThis work made possible by the UK Foreign, Commonwealth Development Office Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, 220757/Z/20/Z); Bill & Melinda Gates Foundation (OPP1209135); philanthropic support donors University Oxford's Research Response Fund (0009109). Additional funders listed "acknowledgments" section.
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