Comprehensive analysis of a novel subtype of immune microenvironment-derived HPV-infected colorectal cancer

• DOI: 10.1016/j.micinf.2024.105315
• Publication Date: 2024-02-27T04:19:55Z
• Authors: Jianlong Zhou; Yongfeng Liu; Yucheng Zhang; Fa Ling; Jiabin Zheng; Xueqing Yao; Zejian Lyu; Huolun Feng; Yong Li
• Keywords: Male; Cohort Studies; Papillomavirus Infections; Tumor Microenvironment; Prevalence; Humans; Female; Middle Aged; Colorectal Neoplasms; Papillomaviridae; Cell Proliferation; Aged

The characteristics of colorectal cancer (CRC) vary depending on the level study and clinical application. current proposed a novel subtype, Human papillomavirus (HPV)-infected CRC, to understand impact HPV CRC. We assessed prevalence implications in CRC by integrating single cohort Guangdong Provincial People's Hospital public dataset. Differential gene, pathway enrichment analysis, immune infiltration analysis were conducted explore patterns HPV-infected Quantitative polymerase chain reaction, cell proliferation, scratch, flow cytometry assays employed validate revealed high infection with rates ranging from 10% 31%. There was also significant increase tumor proliferation showed increased infiltration, including T cells, γδ cytotoxic plasmacytoid dendritic cells (P < 0.05). Furthermore, our findings confirmed that promoted M1 polarization (6.26% 11.07%). Our results demonstrated low ISM2 expression associated less advanced stage 0.001) better survival outcomes = 0.039). Low correlated strong response, potentially contributing improved observed These provided subtype prognosis "hot" microenvironment may be responsive immunotherapy.