Chemical composition and in vitro evaluation of antioxidant, antimicrobial, cytotoxicity and anti-acetylcholinesterase properties of Tunisian Origanum majorana L. essential oil
0301 basic medicine
Microbial Viability
Bacteria
Cell Survival
Phytochemicals
Fungi
Antineoplastic Agents
Microbial Sensitivity Tests
beta Carotene
Antioxidants
Inhibitory Concentration 50
03 medical and health sciences
Anti-Infective Agents
Cell Line, Tumor
Origanum
Acetylcholinesterase
Oils, Volatile
Animals
Humans
Oxidation-Reduction
DOI:
10.1016/j.micpath.2016.03.003
Publication Date:
2016-03-17T09:47:21Z
AUTHORS (5)
ABSTRACT
This study investigated the chemical composition and evaluated the antioxidant, antimicrobial, cytotoxic and anti-acetylcholinesterase properties of Tunisian Origanum majorana essential oil. The findings showed that the oil exhibited high activity, particularly in terms of reducing power and β-Carotene bleaching, inducing higher IC50 values than BHT. The oil showed an important antimicrobial activity against 25 bacterial and fungal strains. In fact, the IZ, MIC and MBC values recorded for the bacterial strains were in the range of 8 ± 0-18.33 ± 0.57 mm, 0.097-3.125 and 0.39-6.25 mg/mL, respectively. The IZ, MIC and MFC values of the fungal strains varied between 11±0-28 ± 0 mm, 0.058-0.468 mg/mL and 0.234-1.875 mg/mL, respectively. A low cytotoxic effect was observed against cancer (Hep-2 and HT29) and continuous cell lineage (Vero), with CC50 values ranging from 13.73 to 85.63 mg/mL. The oil was also evaluated for anti-acetylcholinesterase effects, which showed that it exhibited significant activity with IC50 values reaching 150.33 ± 2.02 μg/mL.
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