Polymicrobial antibiofilm activity of the membranotropic peptide gH625 and its analogue

• DOI: 10.1016/j.micpath.2018.09.027
• Publication Date: 2018-09-16T01:49:59Z
• Authors: E. de Alteriis; L. Lombardi; A. Falanga; M. Napolano; S. Galdiero; A. Siciliano; R. Carotenuto; M. Guida; E. Galdiero
• Keywords: Crystal violet

This work illustrates a new role for the membranotropic peptide gH625 and its derivative gH625-GCGKKK in impairing formation of polymicrobial biofilms. Mixed biofilms composed Candida bacterial species cause frequently infections failure medical silicone devices also show major drug resistance than single-species Inhibition eradication were evaluated by complementary methods: XTT-reduction, crystal violet staining (CV). Our results indicate that gH625-GCGKKKK, better native peptide, strongly inhibited mixed clinical isolates C. tropicalis/S. marcescens aureus reduced biofilm architecture, interfering with cell adhesion polymeric matrix, as well eradicated long-term on surface.