Akkermansia muciniphila ameliorates chronic kidney disease interstitial fibrosis via the gut-renal axis

• DOI: 10.1016/j.micpath.2022.105891
• Publication Date: 2022-11-23T08:53:47Z
• Authors: Tingting Pei; Rong Hu; Fujing Wang; Sixia Yang; Haitong Feng; Qiye Li; Jiaxing Zhang; Shihua Yan; Liliang Ju; Zhuoen He; Zhongxiao Han; Aicheng Yang; Wei Xiao; Yun Ma; Mingqing Wang
• Keywords: Microecology; Akkermansia muciniphila

Chronic kidney disease (CKD) affects approximately 10% of the global population. The abundance Akkermansia muciniphila (AKK) is significantly reduced in CKD patients.This study investigated effects AKK bacteria on damage and renal interstitium rats with CKD.CKD model 5/6 nephrectomy were used. supplemented (2 × 108 cfu/0.2 mL) for 8 weeks.AKK administration suppressed epithelial-mesenchymal transition (EMT), high-throughput 16S rRNA pyrosequencing showed that supplementation restored disordered intestinal microecology rats. also enhanced mucosal barrier function. may regulate reduce interstitial fibrosis by enhancing probiotics reducing to barrier.The results suggest could be a novel therapeutic strategy treating CKD.