Targeting HSP70 for Cancer Therapy

• DOI: 10.1016/j.molcel.2009.10.003
• Publication Date: 2009-10-23T05:15:31Z
• Authors: Lorenzo Galluzzi; Fabrizio Giordanetto; Guido Kroemer
• Keywords: Models, Molecular; 0301 basic medicine; Sulfonamides; Cell Biology; 3. Good health; 03 medical and health sciences; Drug Resistance, Neoplasm; Neoplasms; Animals; Humans; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Molecular Biology

In a recent issue of Molecular Cell, Leu et al. (2009) demonstrate that a chemical inhibitor of HSP70 exerts prominent tumor-selective cytotoxic effects, thereby lending further support to the notion that non-oncogene addiction constitutes a promising target for anticancer therapy.